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Inhibition of exonuclease V after infection of E. coli by bacteriophage T7

1974; Elsevier BV; Volume: 60; Issue: 2 Linguagem: Inglês

10.1016/0006-291x(74)90271-x

1090-2104

Wilfried Wackernagel, Uta Hermanns,

DNA Repair Mechanisms

Exonuclease V (recBC DNase) is inactivated in E. coli between 4 and 7 min after infection by T7. This process requires protein sythesis. The inactivation does not occur when T7 is deficient for its RNA polymerase and thus does not express the genes involved in DNA replication and phage maturation. Some implications of this new function of T7 are discussed with respect to the processes of infection and DNA replication.