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A mitochondrial perspective on cell death

2001; Elsevier BV; Volume: 26; Issue: 2 Linguagem: Inglês

10.1016/s0968-0004(00)01745-x

1362-4326

Paolo Bernardi, Valeria Petronilli, Fabio Di Lisa, Michael Forte,

ATP Synthase and ATPases Research

The role of mitochondria as crucial participants in cell death programs is well established, yet the mechanisms responsible for the release of mitochondrial activators and the role of BCL2 family proteins in this process remain controversial. Here, we point out the limitations of current approaches used to monitor the physiological responses of mitochondria during cell death, the implications arising from modern views of mitochondrial structure, and briefly assess two proposed mechanisms for the release of mitochondrial proteins during apoptosis.