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Excoecarins D, E, and K, from Excoecaria agallocha

2000; American Chemical Society; Volume: 63; Issue: 3 Linguagem: Inglês

10.1021/np990366t

1520-6025

Tenji Konishi, Takao Konoshima, Yasuhiro Fujiwara, Shiu Kiyosawa,

Phytochemistry and Bioactive Compounds

Three novel diterpenoids, excoecarins D, E, and K (1−3), were isolated from Excoecaria agallocha. The structures of 1−3 were established as 3α,18-dihydroxy-3β,20-epoxybeyer-15-ene, (15R,16S)-ent-15,16-epoxybeyeran-3-one, and ent-3β-hydroxykaur-16-en-2-one, respectively, on the basis of extensive NMR experiments and, in the case of 1, by X-ray analysis.