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In vitro activity of terbinafine associated to amphotericin B, fluvastatin, rifampicin, metronidazole and ibuprofen against Pythium insidiosum

2009; Elsevier BV; Volume: 137; Issue: 3-4 Linguagem: Inglês

10.1016/j.vetmic.2009.01.036

1873-2542

Ayrton Sydnei Cavalheiro, Régis Adriel Zanette, Tatiana Borba Spader, Luciane Teresinha Lovato, María Isabel de Azevedo, Sônia de Ávila Botton, Sydney Hartz Alves, Jânio Morais Santúrio,

Mycobacterium research and diagnosis

We evaluated the in vitro activities of terbinafine alone and in combination with amphotericin B, fluvastatin, rifampicin, metronidazole or ibuprofen against 17 clinical isolates of Pythium insidiosum. The assays were based on technique M38-A2, as well as the checkerboard microdilution method. The main synergism observed was by combination of terbinafine plus amphotericin B (41.18%). Antagonisms were observed in combinations of terbinafine with fluvastatin (35.30%) or rifampicin (5.88%).