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Is there a role for GPIs in yeast cell-wall assembly?

1994; Elsevier BV; Volume: 4; Issue: 2 Linguagem: Inglês

10.1016/0962-8924(94)90003-5

1879-3088

Hans de Nobel, Peter N. Lipke,

Legume Nitrogen Fixing Symbiosis

Glycosylphosphatidylinositol (GPI) membrane anchors are essential for the integration of yeast cell adhesion proteins into the cell wall, but mature cell-wall proteins are unlikely to be attached directly to the membrane. We thus propose that GPI-anchored glycoprotein forms are intermediates in a process that crosslinks the major components of the cell wall by transglycosylation. This mechanism may be critical for both the biosynthesis and overall architecture of the cell wall.