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Randomized Clinical Trial Comparing Reduced-Volume Oral Picosulfate and a Prepackaged Low-Residue Diet With 4-Liter PEG Solution for Bowel Preparation

2014; Lippincott Williams & Wilkins; Volume: 57; Issue: 4 Linguagem: Inglês

10.1097/dcr.0000000000000066

1530-0358

Yong Sok Kim, Chang Won Hong, Byung Chang Kim, Kyung Su Han, Ji Won Park, Hyo Seong Choi, Jungnam Joo, Dae Kyung Sohn,

Colorectal Cancer Surgical Treatments

Reduced-volume bowel preparation with a low-residue diet prior to colonoscopy would result in better patient compliance and sufficient bowel preparation.To compare the clinical efficacy of reduced-volume sodium picosulfate and a prepackaged low-residue diet with that of the standard bowel preparation using 4 L of PEG solution.Prospective, single center, single blind, active control, randomized study (NCCCTS-12-619, KCT0000470).Ambulatory outpatient clinic at the National Cancer Center, Republic of Korea.A total of 194 subjects were randomly assigned for this study, 97 in each group. After exclusions, 94 subjects in the Picolight group and 90 in the PEG group completed the study and were analyzed.Sodium picosulfate with a prepackaged low-residue, one-day diet or 4-L PEG for bowel preparation.Success rate of the bowel preparation, tolerability, adverse events, cecal intubation time, polyp detection rate and adenoma detection rate.The bowel preparation success rate was significantly higher (91.5% vs. 81.1%, p = 0.04) and the rates of adverse events, including abdominal distension, pain, nausea, vomiting and abdominal discomfort, were significantly lower in the picosulfate group than the PEG group. Cecal intubation times and the polyp and adenoma detection rates were similar in the 2 groups.Single center, limited population, all colonoscopies were performed in the morning.Bowel preparation with low-volume oral picosulfate and a prepackaged low-residue diet enhances colon cleansing and is better tolerated than the standard bowel preparation.