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Carbapenems in the USA: focus on doripenem

2007; Taylor & Francis; Volume: 5; Issue: 5 Linguagem: Inglês

10.1586/14787210.5.5.793

1744-8336

Philip Lister,

Antibiotic Use and Resistance

The threat of antibacterial resistance continues to increase globally, and therapeutic options for the treatment of some serious infectious diseases are diminishing. The carbapenems are a potent class of broad-spectrum drugs, and their stability against hydrolysis by many important β-lactamases make them an important weapon in the treatment of β-lactamase-producing bacterial pathogens. This review focuses on four carbapenems of clinical importance in the USA: imipenem, meropenem, ertapenem and doripenem. After a historical review of carbapenem development, these four carbapenems are evaluated based on their mechanism of action, spectrum of activity, potency, pharmacodynamics, clinical pharmacokinetics, clinical profiles and toxicity issues.