Growth Promotion by Homocysteic Acid
1976; American Association for the Advancement of Science; Volume: 192; Issue: 4237 Linguagem: Inglês
10.1126/science.1257770
ISSN1095-9203
AutoresP. Clopath, Virginia C. Smith, Kevin K. McCully,
Tópico(s)Algal biology and biofuel production
ResumoHomocysteic acid, HO 3 SCH 2 CH 2 CHNH 2 CO 2 H, promotes growth of hypophysectomized rats, assayed by observation of increased thickness of epiphyseal cartilage of the tibia and by observation of tail growth. Doses of homocysteic acid as low as 1 microgram per day for 4 days in the tibia assay and 2.5 milligrams per kilogram per day for 5 weeks in the tail assay were effective in promoting growth. Serum somatomedin activity, determined by the porcine cartilage disk assay, was also increased by homocysteic acid. These findings relate an area of sulfur amino acid metabolism to the physiological action of growth hormone, accelerated growth in homocystinuria, initiation of arteriosclerosis, and control of cellular growth.
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