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Mechanical and rheological improvement of a calcium phosphate cement by the addition of a polymeric drug

2001; Wiley; Volume: 57; Issue: 1 Linguagem: Inglês

10.1002/1097-4636(200110)57

1097-4636

Maria‐Pau Ginebra, A. Rilliard, E. Fern�ndez, Carlos Elvira, J. San Rom�n, Josep A. Planell,

Endodontics and Root Canal Treatments

Journal of Biomedical Materials ResearchVolume 57, Issue 1 p. 113-118 Mechanical and rheological improvement of a calcium phosphate cement by the addition of a polymeric drug M. P. Ginebra, Corresponding Author M. P. Ginebra [email protected] Research Centre in Biomedical Engineering (CREB), Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya, Av. Diagonal 647, 08028 Barcelona, SpainResearch Centre in Biomedical Engineering (CREB), Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya, Av. Diagonal 647, 08028 Barcelona, SpainSearch for more papers by this authorA. Rilliard, A. Rilliard Research Centre in Biomedical Engineering (CREB), Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya, Av. Diagonal 647, 08028 Barcelona, SpainSearch for more papers by this authorE. Fernández, E. Fernández Research Centre in Biomedical Engineering (CREB), Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya, Av. Diagonal 647, 08028 Barcelona, SpainSearch for more papers by this authorC. Elvira, C. Elvira Instituto de Ciencia y Tecnología de Polímeros, CSIC, Juan de la Cierva 3, 28006 Madrid, SpainSearch for more papers by this authorJ. San Román, J. San Román Instituto de Ciencia y Tecnología de Polímeros, CSIC, Juan de la Cierva 3, 28006 Madrid, SpainSearch for more papers by this authorJ. A. Planell, J. A. Planell Research Centre in Biomedical Engineering (CREB), Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya, Av. Diagonal 647, 08028 Barcelona, SpainSearch for more papers by this author M. P. Ginebra, Corresponding Author M. P. Ginebra [email protected] Research Centre in Biomedical Engineering (CREB), Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya, Av. Diagonal 647, 08028 Barcelona, SpainResearch Centre in Biomedical Engineering (CREB), Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya, Av. Diagonal 647, 08028 Barcelona, SpainSearch for more papers by this authorA. Rilliard, A. Rilliard Research Centre in Biomedical Engineering (CREB), Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya, Av. Diagonal 647, 08028 Barcelona, SpainSearch for more papers by this authorE. Fernández, E. Fernández Research Centre in Biomedical Engineering (CREB), Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya, Av. Diagonal 647, 08028 Barcelona, SpainSearch for more papers by this authorC. Elvira, C. Elvira Instituto de Ciencia y Tecnología de Polímeros, CSIC, Juan de la Cierva 3, 28006 Madrid, SpainSearch for more papers by this authorJ. San Román, J. San Román Instituto de Ciencia y Tecnología de Polímeros, CSIC, Juan de la Cierva 3, 28006 Madrid, SpainSearch for more papers by this authorJ. A. Planell, J. A. Planell Research Centre in Biomedical Engineering (CREB), Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya, Av. Diagonal 647, 08028 Barcelona, SpainSearch for more papers by this author First published: 14 June 2001 https://doi.org/10.1002/1097-4636(200110)57:1 3.0.CO;2-5Citations: 114Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract A polymeric acrylic system supporting a derivative of the aminosalicylic acid was incorporated in a calcium phosphate cement, with the aim not only to achieve some pharmacological effects but to obtain an improvement of its mechanical and rheological properties. It is known that, besides the analgesic and anti-inflammatory properties, the salicylic group presents a calcium complexation ability. The inorganic phase of the cement consisted of α-tricalcium phosphate [α-Ca3(PO4)2] and precipitated hydroxyapatite added as a seed. The liquid phase was an aqueous solution of Na2HPO4. The polymeric drug increased the injectability of the cement. The hydrolysis of the α-tricalcium phosphate into calcium-deficient hydroxyapatite proceeded at a lower rate because of the addition of the polymeric drug. As a consequence, the cement hardening was slightly slower, although the final compressive strength was 25% higher. The bending strength increased from 5 to 9 MPa with the addition of the polymeric drug. The strengthening of the structure was related to the reduction of porosity and the lower size of the precipitated crystals, as observed by scanning electron microscopy. © 2001 John Wiley & Sons, Inc. 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