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A simple synthesis of four stereoisomers of roseoside and their inhibitory activity on leukotriene release from mice bone marrow-derived cultured mast cells

2008; Elsevier BV; Volume: 17; Issue: 1 Linguagem: Inglês

10.1016/j.bmc.2008.11.002

1464-3391

Arata Yajima, Yutaka Oono, Ryusuke Nakagawa, Tomoo Nukada, Goro Yabuta,

Phytochemical Studies and Bioactivities

Four stereoisomers of roseoside (vomifoliol glucosides) were synthesized using glucose as a chiral resolving reagent. The four synthetic stereoisomers exhibited inhibitory activity on leukotriene release from mouse bone marrow-derived cultured mast cells (BMCMC). The (6S)-isomers of roseoside were about twice as active as (6R)-isomers.