Portal de Periódicos da CAPES

Diagnosis of immediate allergic reactions to beta‐lactam antibiotics

2003; Wiley; Volume: 58; Issue: 10 Linguagem: Inglês

10.1034/j.1398-9995.2003.00280.x

1398-9995

Marı́a José Torres, M. Blanca, Javier Fernández, Antonino Romano, A. de Weck, Werner Aberer, Knut Brockow, Werner J. Pichler, P. Démoly,

Respiratory and Cough-Related Research

AllergyVolume 58, Issue 10 p. 961-972 Diagnosis of immediate allergic reactions to beta-lactam antibiotics M. J. Torres, M. J. Torres Allergy Service, Carlos Haya Hospital, Malaga, SpainSearch for more papers by this authorM. Blanca, M. Blanca Allergy Service, University La Paz, Madrid, SpainSearch for more papers by this authorJ. Fernandez, J. Fernandez Allergy Section, Dept. Clin. Med., UMH, Elche, SpainSearch for more papers by this authorA. Romano, A. Romano Allergy Service, Catholic University of Rome, ItalySearch for more papers by this authorA. de Weck, A. de Weck Fondation Gerimmun, Beaumont 18, CH- 1700, Fribourg, SwitzerlandSearch for more papers by this authorW. Aberer, W. Aberer Department of Environmental Dermatology, Graz, AustriaSearch for more papers by this authorK. Brockow, K. Brockow Klinik und Poliklinik für Dermatologie und Allergologie, Muenchen, GermanySearch for more papers by this authorW. J. Pichler, W. J. Pichler Clinic for Rheumatology and Clinical Immunology/Allergy, Inselspital, Bern, SwitzerlandSearch for more papers by this authorP. Demoly, P. Demoly Maladies Respiratoires-INSERM U454, Hopital Arnaud de Villeneuve, Montpellier, FranceSearch for more papers by this authorfor ENDA, for ENDA Allergy Service, Carlos Haya Hospital, Malaga, SpainSearch for more papers by this authorthe EAACI interest group on drug hypersensitivity, the EAACI interest group on drug hypersensitivity Allergy Service, Carlos Haya Hospital, Malaga, SpainSearch for more papers by this author M. J. Torres, M. J. Torres Allergy Service, Carlos Haya Hospital, Malaga, SpainSearch for more papers by this authorM. Blanca, M. Blanca Allergy Service, University La Paz, Madrid, SpainSearch for more papers by this authorJ. Fernandez, J. Fernandez Allergy Section, Dept. Clin. Med., UMH, Elche, SpainSearch for more papers by this authorA. Romano, A. Romano Allergy Service, Catholic University of Rome, ItalySearch for more papers by this authorA. de Weck, A. de Weck Fondation Gerimmun, Beaumont 18, CH- 1700, Fribourg, SwitzerlandSearch for more papers by this authorW. Aberer, W. Aberer Department of Environmental Dermatology, Graz, AustriaSearch for more papers by this authorK. Brockow, K. Brockow Klinik und Poliklinik für Dermatologie und Allergologie, Muenchen, GermanySearch for more papers by this authorW. J. Pichler, W. J. Pichler Clinic for Rheumatology and Clinical Immunology/Allergy, Inselspital, Bern, SwitzerlandSearch for more papers by this authorP. Demoly, P. Demoly Maladies Respiratoires-INSERM U454, Hopital Arnaud de Villeneuve, Montpellier, FranceSearch for more papers by this authorfor ENDA, for ENDA Allergy Service, Carlos Haya Hospital, Malaga, SpainSearch for more papers by this authorthe EAACI interest group on drug hypersensitivity, the EAACI interest group on drug hypersensitivity Allergy Service, Carlos Haya Hospital, Malaga, SpainSearch for more papers by this author First published: 19 September 2003 https://doi.org/10.1034/j.1398-9995.2003.00280.xCitations: 388 Maria Torres, Allergy Service, Carlos Haya Hospital, Malaga, Spain Tel.: +34-951-030346 Fax: +34-951-030302 E-mail: [email protected] Pascal Demoly, ENDA secretary, Maladies Respiratoires - INSERM U454, Hôpital Arnaud de Villeneuve, CHU de Montpellier, 34295 Montpellier cedex 5, France Tel.: +33-467336127 Fax: +33-467042708 E-mail: [email protected] Werner Pichler, ENDA president, Clinic for Rheumatology and Clinical Immunology/Allergology, Inselspital, 3010 Bern, Switzerland Tel.: +41-316322264 Fax: +41-313815735 E-mail: [email protected] ENDA: European Network for Drug Allergy and the EAACI interest group on drug hypersensitivity with the following additional members: Drs B. K. Ballmer-Weber, A. Barbaud, B. Bilo, A. Bircher, J. Birmbaum, B. Blömecke, P. Campi, C. Dzviga, M. Drouet, B. Eberlein-König, T. Frew, T. Fuchs, J.L. Guéant, C. Gutgesell, M. Hertl, G. Kanny, A. Kapp, M. Kidon, M. Kowalski, G. Marone, H. Merk, A.D. Moneret-Vautrin, C. Pascual-Marcos, B. Przybilla, E. Rebelo-Gomes, J. Ring, F. Rueff, A. Sabbah, J. Sainte Laudy, M. Sanz, E. Tas, D. Vervloet, B. Wedi, B. Wüthrich Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 HE Amos. Antigenic determinants of the penicillin molecule. In: HE Amos Eds. Allergic drugs reactions. Oxford: Edward Arnold, 1976; 64–74. 2 Levine BB, Price VH. Studies on the immunological mechanisms of penicillin allergy II. Antigenic specificities of allergic wheal-and-flare skin responses in patients with histories of penicillin allergy. Immunology 1964; 7: 542. 3 Levine BB. Benzylpenicilloyl-specific serum antibodies to penicillin in man II. Sensitivity of the hemagglutination assay method, molecular classes of the antibodies detected, and antibody titters of randomly selected patients. J Immunol 1966; 96: 719–726. 4 Fernandez-Rivas M, Perez Carral C, Cuevas M, Marti C, Moral A, Senent CJ. Selective allergic reactions to clavulanic acid. J Allergy Clin Immunol 1995; 95: 748–750. 5 Candarso AI, Saez-Jiménez SA, Vidal C, Rodríguez M. Aztreonam induced anaphylaxis. Lancet 1990; ii: 746–747. 6 Ahlstedt S, Kristofersson A. Experimental evidence of decreased incidence of penicillin allergy through the use of pure penicillins. Infection 1979; 7: 499–502. 7 Blanca M. Allergic reactions to penicillins. A changing world?. Allergy 1995; 50: 777–782. 8 Blanca M, Vega JM, Garcia J, Miranda A, Carmona MJ, Juarez C, et al. New aspects of allergic reactions to betalactams: crossreactions and unique specifities. Clin Exp Allergy 1994; 24: 407–415. 9 Weiss ME, Adkinson NF. Immediate hypersensitivity reactions to penicillin and related antibiotics. Clin Allergy 1988; 18: 515–540. 10 Cars O, Molstad S, Melander A. Variation in antibiotic use in the European Union. Lancet 2001; 357: 1851–1853. 11 McCaig L, Hughes JM. Trends in antimicrobial drug prescribing among office-based physicians in the United States. JAMA 1995; 273: 214–219. 12 Blanca M, Vega JM, Garcia J, Carmona MJ, Terrados S, Miranda A, et al. Allergy to amoxicillin with good tolerance to other penicillins. Study of the incidence in patients allergic to betalactams. Clin Exp Allergy 1990; 20: 475–481. 13 Silviu Dan F, Mc Philips S, Warrington R. The frequency of skin test reactions to side chain penicillin determinants. J Allergy Clin Immunol 1993; 91: 694–701. 14 Romano A, Mayorga C, Torres MJ, Artesani MC, Suau R, Pérez E, et al. Immediate allergic reactions to cephalosporins: cross-reactivity and selective responses. J Allergy Clin Immunol 2000; 106: 1177–1183. 15 Romano A, Quarantino D, Aimone-Gastin I, Mayorga C, Papa G, Venuti A et al. Cephalosporin allergy:characterization of unique and cross-reacting cephalosporin antigens. Int J Immunopathol Pharmacol 1997; 10: 187–191. 16 Romano A, Blanca M, Mayorga C, Venuti A, Gasbarrini G. Immediate hypersensitivity to penicillins. Studies on Italian subjects. Allergy 1997; 52: 89–93. 17 Blanca M, Mayorga C, Torres MJ, Warrington R, Romano A, Demoly P, et al. Side chain specific reactions to betalactams: Fourteen years later. Clin Exp Allergy 2002; 32: 192–197 18 Levine BB. Immunologic mechanisms of penicillin allergy. A haptenic model system for the study of allergic diseases of man. N Engl J Med 1966; 275: 1115–1125. 19 Torres MJ, Romano A, Mayorga C, Moya MC, Guzman AE, Reche M, et al. Diagnostic evaluation of a large group of patients with immediate allergy to penicillins: the role of skin testing. Allergy 2001; 56: 850–856. 20 Torres MJ, Mayorga C, Leyva L, Guzman A, Cornejo-García JA, Juarez C, Blanca M. Controlled administration of penicillin to patients with a positive history but negative skin and specific serum IgE tests. Clin Exp Allergy 2002; 32: 270–276. 21 Kaplan AP. Urticaria and angioedema. In: Middleton eds. Allergy principles and practice. 5th edn. Mosby, 1998: 1104–1122. 22 Lieberman P. Anaphylaxis and anaphylactoid reactions. In: Middleton Eds. Allergy principles and practice. 5th edn. Mosby, 1998: 1079–1092. 23 Demoly P, Kropf R, Bircher A, Pichler WJ. Drug hypersensitivity questionnaire. Allergy 1999; 54: 999–1003. 24 Torres MJ, Mayorga C, Pamies R, Rodriquez JL, Juarez C, Romano A, Blanca M. Immunological response to different determinants of benzylpenicillin, amoxicillin and ampicillin. Comparison between urticaria and anaphylactic shock. Allergy 1999; 54: 936–943. 25 Gadde J, Spence M, Wheeler B, Adkinson NF Jr. Clinical experience with penicillin skin testing in a large inner-city STD clinic. JAMA 1993; 27: 2456–2463. 26 Brochow K, Romano A, Blanca M, Ring J, Pichler WJ, Demoly P, and ENDA. General considerations for skin test procedures in the diagnosis of drug hypersensitivity. Allergy 2002; 57: 45–51. 27 Parker CW, de Weck AL, Shapiro J, Kern M, Eisen HN. The preparation and some properties of penicillenic acid derivatives relevant to penicillin hypersensitivity. J Exp Med 1962; 115: 803–819. 28 Levine BB, Ovary Z. Studies of the mechanism of the formation of the penicillin antigen III. The N(D-(Benzyl penicilloyl)) group as an antigenic determinant responsible for hypersensitivity to penicillin G. J Exp Med 1961; 114: 875. 29 Levine BB, Redmond AP. Minor haptenic determinant specific reagins of penicillin hypersensitivity in man. Int Arch Allergy Appl Immunol 1969; 35: 445–455. 30 Dewdeney JM. Immunology of the antibiotics. In: M Sela eds. The antigens. Vol 5, New York. Academic Press. 1977: 73–245. 31 Sullivan TJ, Wedner J, Shatz GS, Yecies LD, Parker CW. Skin testing to detect penicillin allergy. J Allergy Clin Immunol 1981; 68: 171–180. 32 Blanca M, Torres MJ, Garcia JJ, Romano A, Mayorga C, de Ramon E, et al. Natural evolution of skin test sensitivity in patients allergic to betalactam antibiotics. J Allergy Clin Immunol 1999; 103: 918–924. 33 De Weck A.L. Penicillins and Cephalosporins. In: A.L. De Weck, H. Bundgaard, Eds. Handbook of Experimental Pharmacology, Springer-Verlag, Berlin, 1983, vol. 63, pp. 423–482. 34 Green GR, Rosenblum AH, Sweet LC. Evaluation of penicillin hypersensitivity: value of clinical history and skin testing with penicilloyl-polylysine and penicillin G. A comparative prospective study of the penicillin study group of the American Academy of Allergy. J Allergy Clin Immunol 1977; 60: 339–345. 35 Parker C. Allergic reactions in man. Pharmacol Rev 1982; 34: 85–104. 36 Van Dellen RG, Walsh WE, Peters GA, Gleich GJ. Differing patterns of wheal and flare skin reactivity in patients allergic to the penicillins. J Allergy 1971; 47: 230–236. 37 Warrington RJ, McPhillips S. Anaphylaxis to Cefazolin without allergy to other betalactam antibiotics. J Allergy Clin Immunol 1996; 98: 460–462. 38 Demoly P, Messaad D, Sahla H, Hillaire-Buys D, Bousquet J. Immediate hypersensitivity to ceftriaxone. Allergy 2000; 55: 418–419. 39 Mendelson LM, Ressler C, Rosen JP, Selcow JE. Routine elective penicillin allergy skin testing in children and adolescents: study of sensitization. J Allergy Clin Immunol 1984; 73: 76–81. 40 Parker PJ, Parrinello JT, Condemi JJ, Rosenfeld SI. Penicillin resensitization among hospitalized patients. J Allergy Clin Immunol 1991; 88: 213–217. 41 Lopez-Serrano MC, Caballero MT, Barranco P, Martinez-Alzamora F. Booster responses in the study of allergic reactions to betalactams antibiotics. J Invest Allergol Clin Immunol 1996; 6: 30–35. 42 Pichichero ME, Pichichero DM. Diagnosis of penicillin, amoxicillin, and cephalosporin allergy: reliability of examination assessed by skin testing and oral challenge. J Pediatr 1998; 132: 137–143. 43 Minguez MA, Zapatero L, Caloto M, Martinez-Molero MI. A study of allergy to penicillin antibiotics in 1995 in the Child Allergy Department of the gregorio Marañon University hospital. Allergol Immunopathol 1998; 26: 43–46. 44 Edwards RG, Spackman DA, Dewdney JM. Development and use of three new radioallergosorbent tests in the diagnosis of penicillin allergy. Int Arch Allergy Appl Immunol 1982; 68: 352–357. 45 Bolzacchini E, Consonni V, Gramatica P, Meinardi S, Orlandi M, Rindone B, et al. Towards an in vitro test for the diagnosis of allergy to penicillins. Synthesis, characterization and use of betalactam and betalactam metabolite poly-L-lysines which recognize human IgE antibodies. Bioconjugate Chemistry 1999; 10: 332–337. 46 Harle DG, Baldo BA. Drugs as allergens: An immunoassay for detecting IgE antibodies to cephalosporins. Int Arch Allergy Appl Immunol 1990; 92: 439–444. 47 Blanca M, Mayorga C, Torres MJ, Reche M, Moya MC, Rodriguez JL, et al. Clinical evaluation of Pharmacia CAP SystemTM RAST FEIA amoxicilloyl and benzylpenicilloyl in patients with penicillin allergy. Allergy 2001; 56: 862–870, 48 Blanca M, Mayorga C, Perez E, Suau R, Juarez C, Vega JM, et al. Determination of IgE antibodies to the benzylpenicilloyl determinant. A comparison between poly-L-lysine and human serum albumin as carriers. J Immunol Methods 1992; 153: 99–105. 49 Sanz ML, Gamboa PM, Antepara I, Uasuf C, Vila L, Garcia-Aviles C, et al. Flow cytometric basophil activation test by detection of CD63 expression in patients with immediate-type reactions to beta-lactam antibiotics. Clin Exp Allergy 2002; 32: 277–286. 50 Romano A, Di Fonso M, Papa G, Pietrantonio F, Federico F, Fabrizi G, Venuti A. Evaluation of adverse cutaneous rections to aminopenicillins with emphasis on those manifested by maculopaulopapular rashes. Allergy 1995; 50: 113–118. 51 Kraft D, Wide L. Clinical patterns and results of radioallergosorbent test (RAST) and skin tests in penicillin allergy. Br J Dermatol 1976; 94: 593–601. 52 Schwartz LB, Bradford TR, Rouse C, Irani A-M, Rasp G, van der Zwan JK. Development of a new, more sensitive immunoassay for human tryptase: Use in systemic anaphylaxis. J Clin Immunol 1994; 14: 190–204. 53 Schwartz LB, Metcalfe DD, Miller JS, Earl H, Sullivan T. Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis. N Engl J Med 198725; 316: 1622–1626. 54 Schwartz LB, Yunginger JW, Miller J, Bokhari R, Dull D. Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis. J Clin Invest 1989; 83: 1551–1555. 55 Schwartz LB, Irani AM. Serum tryptase and the laboratory diagnosis of systemic mastocytosis. Hematol Oncol Clin North Am 2000; 14: 641–657. 56 Demoly P, Lebel B, Messaad D, Sahla H, Rongier M, Daurès JP, et al. Predictive capacity of histamine release for the diagnosis of drug allergy. Allergy 1999; 54: 500–506. 57 Bircher AJ, Haldimann D, Weber J. CAST-ELISA testing for the diagnosis of immediate-type allergic reactions to betalactam antibiotics. Allergy Clin Immunol Int 1996; 8: 109–110. 58 Lebel B, Messaad D, Kvedariene V, Rongier M, Bousquet J, Demoly P. Cystenyl-leukotriene release test (CAST) in the diagnosis of immediate drug reactions. Allergy 2001; 56: 688–692. 59 De Weck AL, Stadler BM, Urwyler A, Wehwee HU, Buhlmann RP. Cellular allergen stimulation (CAST). Allergy Clin Immunology News 1993; 5: 9–14. 60 Sanz ML, Gamboa PM, de Weck AL. Clinical evaluation of in vitro tests in diagnosis of immediate allergic reactions to betalactam antibiotics. Allergy Clin Immunol International 2002; 14: (in press). 61 Sabbah A, Lauret MG, Maillard H. Preliminary study of basophil activation test for drug allergy using anti-membrane antibodies and flow cytometry. Allergie Immunol 1995; 27: 276–277. 62 Crockard AD, Ennis M. Laboratory-based allergy diagnosis: should we go with the flow? Clin Exp Allergy 2001; 31: 975–977. 63 Baldo BA. Penicillins and cephalosporins as allergens-structural aspects of recognition and cross-reactions. Clin Exp Allergy 1999; 29: 744–749. 64 Ponvert C, Le Clainche L, de Blic J, Le Bourgeois M, Sscheinmann P, Paupe J. Allergy to betalactam antibiotics in children. Pediatrics 1999; 104: 954–955. Citing Literature Volume58, Issue10October 2003Pages 961-972 ReferencesRelatedInformation