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BIBTEX RIS

Pro-inflammatory cytokines and soluble receptors in response to acute psychosocial stress: Differential reactivity in bipolar disorder

2014; Elsevier BV; Volume: 580; Linguagem: Inglês

10.1016/j.neulet.2014.07.040

1872-7972

Andréa Wieck, Rodrigo Grassi‐Oliveira, Carine Hartmann do Prado, Lucas B. Rizzo, Agatha Schommer de Oliveira, Júlia Kommers-Molina, Thiago Wendt Viola, Érica Leandro Marciano Vieira, Antônio Lúcio Teixeira, Moisés Evandro Bauer,

Stress Responses and Cortisol

Mounting evidence suggests a chronic pro-inflammatory state in individuals with bipolar disorder (BD). Stress exposure is known to exacerbate several inflammatory conditions as well as psychiatric disorders. Here, we analyzed plasma levels of pro-inflammatory cytokines and their soluble receptors to realistic acute psychosocial stress challenge in BD. Thirteen euthymic type 1 BD patients and 15 matched controls underwent the Trier Social Stress Test protocol (TSST). Blood samples were collected before and after TSST and plasma cytokines interleukin IL-2, IL-6, IL-33, and tumor necrosis factor alpha (TNF-α) were measured. In addition TNF-α soluble receptors TNFR1 and TNFR2, and IL-33 soluble receptor sST2 were assessed. Increased IL-33 and reduced sST2 levels were observed in BD subjects as compared to controls, independently of stress exposure. Following TSST, there were higher levels of IL-2 and reduced levels of sTNFR1 in both groups. However, the magnitude change for both cytokines was found higher in controls than BD subjects. Our data suggest that BD patients have differential stress reactivity as compared to controls, possibly related to an immunologic imbalance and failure of regulatory mechanisms.