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Immune reconstitution following hematopoietic stem-cell transplantation

2007; Elsevier BV; Volume: 20; Issue: 2 Linguagem: Inglês

10.1016/j.beha.2006.09.009

1532-1924

Michelle Geddes, Jan Storek,

Neutropenia and Cancer Infections

Hematopoietic stem-cell transplantation is associated with a profound immune deficiency manifested as an increased propensity to develop infections and probably also malignancies. Innate immunity, including epithelial barriers and phagocytes, typically recovers within weeks after grafting, and B-cell counts and CD8 T-cell counts recover within months. CD4 T-cell counts are low for years, and their recovery is particularly slow in older patients with poor thymic function. Therapies to improve immune function include vaccinations, immunoglobulins for recurrent infections, cytokines, and antigen-specific donor lymphocyte infusions.