Close linkage between genes which cause hairlessness in the mouse
1967; Cambridge University Press; Volume: 9; Issue: 1 Linguagem: Inglês
10.1017/s001667230001034x
ISSN1469-5073
AutoresS. P. Flanagan, J. H. Isaacson,
Tópico(s)Wnt/β-catenin signaling in development and cancer
Resumo1. A new semi-dominant gene called shaven ( Sha ) causes hairlessness in the mouse and it is closely linked to naked. Homozygous shaven mice never grow a first coat and adults grow a few short hairs only. Shaven heterozygotes grow a full coat which is greasy. 2. The percentage recombination between shaven and naked was found to be 0·8%. Three-point tests with naked and caracul showed that the order of the three loci is either N–Sha–Ca or N–Ca–Sha . 3. The failure of homozygous shaven mice to grow a coat is due to abnormal keratinization of the hairs in the follicles. The follicles were found to be deficient in sulphydryl groups. 4. The greasiness of the Sha + coat is due to the presence of a sudanophilic fluid in the hair medullae. 5. The close linkage between the two genes with similar phenotypic effects is discussed.
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