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Selective Recognition of Cysteine in Its Free and Protein‐Bound States by the Zn 2+ Complex of a Triazole‐Based Calix[4]arene Conjugate

2011; Wiley; Volume: 17; Issue: 50 Linguagem: Inglês

10.1002/chem.201102791

1521-3765

Rakesh Pathak, Khatija Tabbasum, Vijaya Kumar Hinge, Chebrolu P. Rao,

Amino Acid Enzymes and Metabolism

Chemistry – A European JournalVolume 17, Issue 50 p. 13999-14003 Communication Selective Recognition of Cysteine in Its Free and Protein-Bound States by the Zn2+ Complex of a Triazole-Based Calix[4]arene Conjugate Rakesh Kumar Pathak, Rakesh Kumar Pathak Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076 (India), Fax: (+91) 22-2576-7152Search for more papers by this authorKhatija Tabbasum, Khatija Tabbasum Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076 (India), Fax: (+91) 22-2576-7152Search for more papers by this authorVijaya Kumar Hinge, Vijaya Kumar Hinge Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076 (India), Fax: (+91) 22-2576-7152Search for more papers by this authorProf. Chebrolu Pulla Rao, Corresponding Author Prof. Chebrolu Pulla Rao [email protected] Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076 (India), Fax: (+91) 22-2576-7152Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076 (India), Fax: (+91) 22-2576-7152Search for more papers by this author Rakesh Kumar Pathak, Rakesh Kumar Pathak Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076 (India), Fax: (+91) 22-2576-7152Search for more papers by this authorKhatija Tabbasum, Khatija Tabbasum Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076 (India), Fax: (+91) 22-2576-7152Search for more papers by this authorVijaya Kumar Hinge, Vijaya Kumar Hinge Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076 (India), Fax: (+91) 22-2576-7152Search for more papers by this authorProf. Chebrolu Pulla Rao, Corresponding Author Prof. Chebrolu Pulla Rao [email protected] Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076 (India), Fax: (+91) 22-2576-7152Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076 (India), Fax: (+91) 22-2576-7152Search for more papers by this author First published: 14 November 2011 https://doi.org/10.1002/chem.201102791Citations: 21Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Zinc-ed in: A highly fluorescent zinc complex of triazole-linked calix[4]arene (see scheme), [ZnL], for the selective recognition of Cys and other protein-bound/free thiols in the blood-serum milieu by mimicking the Zn2+-induced redox switch has been developed. References 1 1aJ. M. Berg, Y. Shi, Science 1996, 271, 1081; 1bY. Shi, J. M. Berg, Science 1995, 268, 282; 1cI. L. Alberts, K. Nadassy, S. J. Wodak, Protein Sci. 1998, 7, 1700. 2 2aW. Maret, Proc. Natl. Acad. Sci. USA 1994, 91, 237; 2bD. Summa, O. Spiga, A. Bernini, V. Venditti, R. Priora, S. Frosali, A. Margaritis, D. D. Giuseppe, N. Niccolai, P. D. Simplicio, Proteins Struct. Funct. Bioinf. 2007, 69, 369; 2cD. M. Ralph, S. R. Robinson, M. S. Campbell, G. M. Bishop, Free Radical Biol. Med. 2010, 49, 649. 3aT. Finkel, N. J. Holbrook, Nature 2000, 408, 239; 3bC. J. Chang, J. Jaworski, E. M. Nolan, M. Sheng, S. J. Lippard, Proc. Natl. Acad. Sci. USA 2004, 101, 1129; 3cE. Aizenman, A. K. 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Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description chem_201102791_sm_miscellaneous_information.pdf1.3 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume17, Issue50December 9, 2011Pages 13999-14003 ReferencesRelatedInformation