Heterotopic neural transplants in the cerebellum of the rat: their afferents
1980; Elsevier BV; Volume: 196; Issue: 1 Linguagem: Inglês
10.1016/0006-8993(80)90731-3
ISSN1872-6240
AutoresBrian H. Hallas, Monica M. Oblinger, Gopal D. Das,
Tópico(s)Genetic Syndromes and Imprinting
ResumoThis chapter reviews succinctly lesion and transplantation experiments showing the existence of axon-guidance cues in the adult central nervous system (CNS), as well as the capacity of mature neurons to recognize and respond to such cues in the mature CNS, or in grafted peripheral or fetal neural tissues. The chapter describes an experimental model that will lead to the identification of axon-guidance molecules for mature 5-HT neurons. Several inhibitory molecules have been identified as being responsible for the poor regenerative capacities of CNS neurons. However, a reduction in the level of growth-promoting or axon-guidance molecules might also contribute in turning the balance towards inhibition. Lesion and transplantation experiments suggested that guidance molecules are still present in the adult CNS, but adult neurons might require some priming to respond to these signals. A better knowledge of growth-promoting or guidance molecules might allow their manipulation to turn back the balance towards appropriately directed axon growth.
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