Brachial-Ankle Pulse Wave Velocity as a Predictor of Mortality in Elderly Chinese
2014; Lippincott Williams & Wilkins; Volume: 64; Issue: 5 Linguagem: Inglês
10.1161/hypertensionaha.114.04063
ISSN1524-4563
AutoresChang‐Sheng Sheng, Yan Li, Lihua Li, Qi‐Fang Huang, Wei‐Fang Zeng, Yuan‐Yuan Kang, Lu Zhang, Ming Liu, Fang‐Fei Wei, Ge-Le Li, Jie Song, Shuai Wang, Ji‐Guang Wang,
Tópico(s)Heart Rate Variability and Autonomic Control
ResumoPulse wave velocity (PWV) is a measure of arterial stiffness and predicts cardiovascular events and mortality in the general population and various patient populations. In the present study, we investigated the predictive value of brachial-ankle PWV for mortality in an elderly Chinese population. Our study subjects were older (≥60 years) persons living in a suburban town of Shanghai. We measured brachial-ankle PWV using an automated cuff device at baseline and collected vital information till June 30, 2013, during follow-up. The 3876 participants (1713 [44.2%] men; mean [±SD] age, 68.1±7.3 years) included 2292 (59.1%) hypertensive patients. PWV was on average 17.8 (±4.0) m/s and was significantly ( P <0.0001) associated with age ( r =0.48) and in unadjusted analysis with all-cause (n=316), cardiovascular (n=148), stroke (n=46), and noncardiovascular mortality (n=168) during a median follow-up of 5.9 years. In further adjusted analysis, we studied the risk of mortality according to the decile distributions of PWV. Only the subjects in the top decile (23.3–39.3 m/s) had a significantly ( P ≤0.003) higher risk of all-cause mortality (hazard ratio relative to the whole study population, 1.56; 95% confidence interval, 1.16–2.08), especially in hypertensive patients (hazard ratio, 1.86; 95% confidence interval, 1.31–2.64; P =0.02 for the interaction between PWV and hypertension). Similar trends were observed for cardiovascular, stroke, and noncardiovascular mortality, although statistical significance was not reached ( P ≥0.08). In conclusion, brachial-ankle PWV predicts mortality in elderly Chinese on the conditions of markedly increased PWV and hypertension.
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