Portal de Periódicos da CAPES

The type III secretion system of Pseudomonas aeruginosa: infection by injection

2009; Nature Portfolio; Volume: 7; Issue: 9 Linguagem: Inglês

10.1038/nrmicro2199

1740-1534

Alan R. Hauser,

Vibrio bacteria research studies

Pseudomonas aeruginosauses a type III secretion system to proliferate within the host. Here, Alan Hauser describes the regulation of the formation of this secretion system, the components that allow the transfer of effectors into the host and the activity of these effectors. The Gram-negative bacterium Pseudomonas aeruginosa uses a complex type III secretion apparatus to inject effector proteins into host cells. The configuration of this secretion machinery, the activities of the proteins that are injected by it and the consequences of this process for infection are now being elucidated. This Review summarizes our current knowledge of P. aeruginosa type III secretion, including the secretion and translocation machinery, the regulation of this machinery, and the associated chaperones and effector proteins. The features of this interesting secretion system have important implications for the pathogenesis of P. aeruginosa infections and for other type III secretion systems.