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Cancer as a Complex Genetic Trait

2002; Cell Press; Volume: 108; Issue: 2 Linguagem: Inglês

10.1016/s0092-8674(02)00622-0

1097-4172

Allan Balmain,

BRCA gene mutations in cancer

Cancer directly affects at least one-third of the human population, but the inherited genetic determinants of cancer risk remain largely unknown. Mouse models of human cancer are helping us to understand this disease as a complex genetic trait and thus to identify the multiple genetic variant alleles involved in pathways that affect individual cancer susceptibility.