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A Nonlinear Relationship between Cerebral Serotonin Transporter and 5-HT 2A Receptor Binding: An In Vivo Molecular Imaging Study in Humans

2010; Society for Neuroscience; Volume: 30; Issue: 9 Linguagem: Inglês

10.1523/jneurosci.2852-09.2010

1529-2401

David Erritzøe, Klaus K. Holst, Vibe G. Frøkjær, Cecilie Löe Licht, Jan Kalbitzer, Finn Årup Nielsen, Claus Svarer, Jacob Madsen, Gitte M. Knudsen,

Neuroscience and Neuropharmacology Research

Serotonergic neurotransmission is involved in the regulation of physiological functions such as mood, sleep, memory, and appetite. Within the serotonin transmitter system, both the postsynaptically located serotonin 2A (5-HT 2A ) receptor and the presynaptic serotonin transporter (SERT) are sensitive to chronic changes in cerebral 5-HT levels. Additionally, experimental studies suggest that alterations in either the 5-HT 2A receptor or SERT level can affect the protein level of the counterpart. The aim of this study was to explore the covariation between cerebral 5-HT 2A receptor and SERT in vivo in the same healthy human subjects. Fifty-six healthy human subjects with a mean age of 36 ± 19 years were investigated. The SERT binding was imaged with [ 11 C]3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB) and 5-HT 2A receptor binding with [ 18 F]altanserin using positron emission tomography. Within each individual, a regional intercorrelation for the various brain regions was seen with both markers, most notably for 5-HT 2A receptor binding. An inverted U-shaped relationship between the 5-HT 2A receptor and the SERT binding was identified. The observed regional intercorrelation for both the 5-HT 2A receptor and the SERT cerebral binding suggests that, within the single individual, each marker has a set point adjusted through a common regulator. A quadratic relationship between the two markers is consistent with data from experimental studies of the effect on SERT and 5-HT 2A receptor binding of chronic changes in 5-HT levels. That is, the observed association between the 5-HT 2A receptor and SERT binding could be driven by the projection output from the raphe nuclei, but other explanations are also at hand.