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Mutations in fusA Associated with Posttherapy Fusidic Acid Resistance in Clostridium difficile

2007; American Society for Microbiology; Volume: 51; Issue: 5 Linguagem: Inglês

10.1128/aac.01283-06

1098-6596

Torbjörn Norén, Thomas Åkerlund, Marlene Wullt, Lars Burman, Magnus Unemo,

Antibiotic Resistance in Bacteria

In silico, we identified fusA (2,067 bp) in Clostridium difficile 630. Sequencing of fusA in posttherapy fusidic acid-resistant C. difficile isolates from 12 patients with C. difficile-associated diarrhea (CDAD) identified fusA mutations, one or two nonsynonymous substitutions, or in one case a deletion of one codon associated with resistance. Five of these mutations have previously been described in fusA of fusidic acid-resistant Staphylococcus aureus, but seven were novel fusA mutations. Fusidic acid monotherapy for CDAD seemed to rapidly select conserved resistant mutants.