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Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus

2014; National Academy of Sciences; Volume: 111; Issue: 22 Linguagem: Inglês

10.1073/pnas.1324197111

1091-6490

Michael Worobey, Guan‐Zhu Han, Andrew Rambaut,

interferon and immune responses

Significance The origin of the 1918 pandemic influenza A virus (IAV) and the reasons for its unusual severity are two of the foremost biomedical mysteries of the past century. We infer that the virus arose via reassortment between a preexisting human H1 IAV lineage and an avian virus. Phylogenetic, seroarcheological, and epidemiological evidence indicates those born earlier or later than ∼1880–1900 would have had some protection against the 1918 H1N1 virus, whereas many young adults born from ∼1880–1900 may have lacked such protection because of childhood exposure to an antigenically distinct H3N8 virus. Our findings suggest that better understanding of how initial exposure shapes lifetime immunity may enhance the prediction and control of future IAV pandemics and seasonal epidemics.