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Response of Apolipoprotein AIV and Lipoproteins to Glycaemic Control in Young People with Insulin-dependent Diabetes Mellitus

1997; Wiley; Volume: 14; Issue: 3 Linguagem: Inglês

10.1002/(sici)1096-9136(199703)14

1464-5491

N. Attia, A. Touzani, M Lahrichi, A. Balafrej, Ouafae Kabbaj, Anik Girard-Globa,

Diabetes Treatment and Management

Diabetic MedicineVolume 14, Issue 3 p. 242-247 Original Article Response of Apolipoprotein AIV and Lipoproteins to Glycaemic Control in Young People with Insulin-dependent Diabetes Mellitus N. Attia, N. Attia Groupe Lipoprotéines, Faculté de Médecine X, Bichat, B.P. 416, 75870 Paris cedex 18, FranceSearch for more papers by this authorA. Touzani, A. Touzani Faculté de Médecine et de Pharmacie, Rabat, MoroccoSearch for more papers by this authorM. Lahrichi, M. Lahrichi Faculté de Médecine et de Pharmacie, Rabat, MoroccoSearch for more papers by this authorA. Balafrej, A. Balafrej Hôpital d'Enfants, Rabat, MorrocoSearch for more papers by this authorO. Kabbaj, O. Kabbaj Faculté de Médecine et de Pharmacie, Rabat, MoroccoSearch for more papers by this authorA. Girard-Globa, Corresponding Author A. Girard-Globa Groupe Lipoprotéines, Faculté de Médecine X, Bichat, B.P. 416, 75870 Paris cedex 18, FranceLaboratoire du Métabolisme des Lipoprotéines Hôpital de l'Antiquaille, 1 rue de l'Antiquaille, 69321 Lyon cedex 05, FranceSearch for more papers by this author N. Attia, N. Attia Groupe Lipoprotéines, Faculté de Médecine X, Bichat, B.P. 416, 75870 Paris cedex 18, FranceSearch for more papers by this authorA. Touzani, A. Touzani Faculté de Médecine et de Pharmacie, Rabat, MoroccoSearch for more papers by this authorM. Lahrichi, M. Lahrichi Faculté de Médecine et de Pharmacie, Rabat, MoroccoSearch for more papers by this authorA. Balafrej, A. Balafrej Hôpital d'Enfants, Rabat, MorrocoSearch for more papers by this authorO. Kabbaj, O. Kabbaj Faculté de Médecine et de Pharmacie, Rabat, MoroccoSearch for more papers by this authorA. Girard-Globa, Corresponding Author A. Girard-Globa Groupe Lipoprotéines, Faculté de Médecine X, Bichat, B.P. 416, 75870 Paris cedex 18, FranceLaboratoire du Métabolisme des Lipoprotéines Hôpital de l'Antiquaille, 1 rue de l'Antiquaille, 69321 Lyon cedex 05, FranceSearch for more papers by this author First published: 19 July 2004 https://doi.org/10.1002/(SICI)1096-9136(199703)14:3 3.0.CO;2-1Citations: 18AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Young people with insulin-dependent diabetes mellitus (IDDM) (n = 104, 7 to 19 years old) were classified into groups of good (I), fair (II), and poor (III) diabetic control and compared to 22 healthy controls of same origin and age range. Triglycerides (TG) were significantly elevated with respect to controls only in group III, and total cholesterol was increased by over 40 % (p < 0.01) mainly due to low density lipoprotein-cholesterol (LDL-C). Apolipoprotein B (apo B) was over 40 % higher in groups II and III. TG, LDL-C, and apo B concentrations all positively correlated with HbA1c levels. Neither HDL-C nor apolipoprotein AI (apo AI) were affected by glycaemic control, but phospholipids were increased in all three subgroups of IDDM subjects (p < 0.001). Over the course of 6 months' treatment, TG, apo B, and LDL-C varied in parallel with HbA1c, confirming a tight association with the quality of glycaemic control. Apolipoprotein AIV (apo AIV) was higher in all groups and closely related to glycaemic control (r = +0.43, p < 0.001), independent of TG or HDL. The specific and sensitive response of apo AIV to insulin deficiency suggests a direct effect at the level of intestinal synthesis. © 1997 by John Wiley & Sons, Ltd. Citing Literature Volume14, Issue3March 1997Pages 242-247 RelatedInformation