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BIBTEX RIS

Myeloperoxidase Inhibitory and Radical Scavenging Activities of Flavones from Pterogyne nitens

2008; Pharmaceutical Society of Japan; Volume: 56; Issue: 5 Linguagem: Inglês

10.1248/cpb.56.723

ISSN

1347-5223

Autores

Daniara Cristina Fernandes, Luís Octávio Regasini, José Carlos Rebuglio Vellosa, Patrícia Mendonça Pauletti, Ian Castro‐Gamboa, Vanderlan da Silva Bolzani, Olga Maria Mascarenhas de Faria Oliveira, Dulce Helena Siqueira Silva,

Tópico(s)

Bioactive natural compounds

Resumo

Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-β-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-β-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1—6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox®.

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