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BIBTEX RIS

Wnt-Related Molecules and Signaling Pathway Equilibrium in Hematopoiesis

2009; Elsevier BV; Volume: 4; Issue: 1 Linguagem: Inglês

10.1016/j.stem.2008.12.004

ISSN

1934-5909

Autores

Sachin Malhotra, Paul W. Kincade,

Tópico(s)

Kruppel-like factors research

Resumo

There is near consensus that Wnt family molecules establish important gradients within niches where hematopoietic stem cells (HSC) reside. We review recent papers suggesting that a delicate balance is required between competing Wnt ligands and corresponding signaling pathways to maintain HSC integrity. Some steps in the transitions from HSC to lymphoid progenitor seem to be partially reversible and under the influence of Wnts. In addition, it has been recently suggested that HSC can oscillate between dormant versus active or lineage-biased states. We speculate that Wnts control a reflux process that may sustain stem cell self-renewal and differentiation potential.

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