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BIBTEX RIS

Parecoxib reduces renal injury in an ischemia/reperfusion model in rats

2015; Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia; Volume: 30; Issue: 4 Linguagem: Inglês

10.1590/s0102-865020150040000006

ISSN

1678-2674

Autores

José Pedro Calistro Neto, Rômulo da Costa Torres, Giovanna Maria Gonçalves, Leopoldo Muniz da Silva, Maria Aparecida Custódio Domingues, Norma Sueli Pinheiro Módolo, Guilherme Antônio Moreira de Barros,

Tópico(s)

Anesthesia and Sedative Agents

Resumo

To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.Parecoxib resulted in renal protection in this experimental model.

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