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In-111 WBC Imaging of Osteomyelitis in Patients With Underlying Bone Scan Abnormalities

1996; Lippincott Williams & Wilkins; Volume: 21; Issue: 3 Linguagem: Inglês

10.1097/00003072-199603000-00001

1536-0229

Anna Kolindou, Yü Liu, Kutlan Özker, ARTHUR Z. KRASNOW, ALI T. ISITMAN, Robert S. Hellman, B. David Collier,

Infectious Diseases and Tuberculosis

One hundred seven combined In-111 WBC/Tc-99m MDP scans performed on 87 patients with a high clinical suspicion of osteomyelitis were retrospectively reviewed. An 86% sensitivity and a 94% specificity for detecting osteomyelitis were found. In addition, patients were grouped into one of five clinical settings for more detailed analysis: diabetic osteoarthropathy, previous arthroplasty, fracture, overlying skin ulcer, and other etiology. Forty-seven studies were performed while patients received antibiotic therapy without loss of sensitivity for detecting osteomyelitis. Results obtained with scintigraphy compared favorably to other imaging and laboratory studies used to detect osteomyelitis. In conclusion, the combined In-111 WBC/Tc-99m MDP scan is a very sensitive and specific method to detect osteomyelitis in patients with concurrent diabetic osteoarthropathy, fracture, postoperative healing, and overlying skin ulcer. Antibiotic treatment does not appear to adversely affect the sensitivity of these scans.