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Role of nitric oxide in the gastric cytoprotection induced by central vagal stimulation

1993; Elsevier BV; Volume: 240; Issue: 2-3 Linguagem: Inglês

10.1016/0014-2999(93)90913-3

1879-0712

Ágnes Király, Gábor Sütő, Yvette Taché,

Neuropeptides and Animal Physiology

The role of nitric oxide (NO) in the vagal cholinergic-mediated cytoprotective effect of intracisternal (i.c.) injection of the stable thyrotropin-releasing hormone (TRH) analog, RX 77368, was investigated in conscious rats. RX 77368 (1.5 ng i.c.) reduced by 88% gastric hemorrhagic lesions induced by oral administration of ethanol (60%). L-NG-Nitro-arginine methyl ester (L-NAME, 3 mg/kg i.v.), an inhibitor of NO synthase, abolished the cytoprotection provided by i.c. RX 77368. The effect of L-NAME was reversed by L- but not D-arginine. These results suggest that the L-arginine-nitric oxide pathway is involved in the cytoprotective effect of i.c. TRH analog, probably through the modulation of gastric mucosal blood flow.