Apolipoprotein E and β-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent
1999; Elsevier BV; Volume: 843; Issue: 1-2 Linguagem: Inglês
10.1016/s0006-8993(99)01894-6
ISSN1872-6240
AutoresUwe Beffert, Jeffrey S. Cohn, Caroline Petit-Turcotte, Michel Tremblay, Nicole Aumont, Charles Ramassamy, Jean Davignon, Judes Poirier,
Tópico(s)Cholinesterase and Neurodegenerative Diseases
ResumoThe ϵ4 allele of apolipoprotein E (apoE) is associated with increased risk for the development of Alzheimer's disease (AD), possibly due to interactions with the β-amyloid (Aβ) protein. The mechanism by which these two proteins are linked to AD is still unclear. To further assess their potential relationship with the disease, we have determined levels of apoE and Aβ isoforms from three brain regions of neuropathologically confirmed AD and non-AD tissue. In two brain regions affected by AD neuropathology, the hippocampus and frontal cortex, apoE levels were found to be decreased while Aβ1–40 levels were increased. Levels of apoE were unchanged in AD cerebellum. Furthermore, levels of apoE and Aβ1–40 were found to be apoE genotype dependent, with lowest levels of apoE and highest levels of Aβ1–40 occurring in ϵ4 allele carriers. These results suggest that reduction in apoE levels may give rise to increased deposition of amyloid peptides in AD brain.
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