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Langerhans Cells and Serum Precipitating Antibodies against Fungal Antigens in Bronchioloalveolar Cell Carcinoma: Possible Association with Pulmonary Eosinophilic Granuloma

1980; Taylor & Francis; Volume: 1; Issue: 1 Linguagem: Inglês

10.3109/01913128009141392

1521-0758

Samuel P. Hammar, Dawn Bockus, Franque Remington, Keith O. Hallman, Richard H. Winterbauer, Lucius D. Hill, Donald E. Bauermeister, Hugh W. Jones, Ralph P. Mennemeyer, Roger F. Wheelis,

Medical Imaging and Pathology Studies

In an ultrastructural study of 37 cases of bronchioloalveolar cell carcinoma (BAC), we identified seven cases (19%) in which Langerhans cells (LC) were closely associated with tumor cells. Serum precipitating antibodies against Aspergillus species and/or thermophilic actinomyces were present in five BAC patients whose tumors contained LC and in six patients whose tumors lacked LC. In a simultaneous study we identified marked atypical bronchiolar and alveolar lining cell hypertrophy and hyperplasma in pulmonary eosinophilic granuloma (PEG). Our data plus current information suggesting that PEG is a form of hypersensitivity pneumonitis support our hypothesis that those cases of BAC in which LC are present may rise in localized or diffuse pulmonary scars caused by PEG.