Portal de Periódicos da CAPES

Human regulatory T cells and autoimmunity

2008; Wiley; Volume: 38; Issue: 4 Linguagem: Inglês

10.1002/eji.200738104

1521-4141

Cristina M. Costantino, Clare Baecher‐Allan, David A. Hafler,

Immunotherapy and Immune Responses

Abstract CD4 + CD25 + regulatory T cells (Treg) appear to be critical in regulating immune responses to self‐antigens. Treg deficiency is associated with several human autoimmune diseases. Although substantial progress has been made in the study of murine and human Treg, their fundamental mechanism of action remains unknown. In this review, we discuss the phenotype of human natural Treg, their functional mechanism, and their role in autoimmune disease. See accompanying commentary: http://dx.doi.org/10.1002/eji.200738120