Autoimmune diseases in HIV-infected patients: 52 cases and literature review
2014; Elsevier BV; Volume: 13; Issue: 8 Linguagem: Inglês
10.1016/j.autrev.2014.04.005
ISSN1873-0183
AutoresL. Iordache, Odile Launay, Olivier Bouchaud, Vincent Jeantils, Cécile Goujard, François Boué, P. Cacoub, Thomas Hanslik, Alfred Mahr, Olivier Lambotte, O. Fain, J.-L. Delassus, Robin Dhôte, R Fior, Lionel Galicier, Loı̈c Guillevin, P. Honoré, Maria Mirabela Manea, A. Mékinian, Mathilde de Menthon, Hilario Nunès, Évangéline Pillebout, Mariem Raho, Laurence Weiss,
Tópico(s)Pneumocystis jirovecii pneumonia detection and treatment
Resumo1) To describe autoimmune diseases (AD) in HIV-infected people; and 2) to perform a literature review concerning this issue. 52 HIV-infected patients that presented an AD in 14 medical departments in Paris and Ile-de-France area were retrospectively included in this study. The ADs were vasculitis (11), immune cytopenias (8), rheumatic diseases (8), lupus (7), sarcoidosis (7), thyroid diseases (6), hepatic diseases (5), and antiphospholipid syndrome (4). Four patients presented 2 ADs. In 5 patients the AD preceded HIV infection, in 14 HIV infection was diagnosed at the same time as the AD and 34 were HIV-infected when they developed an AD. 40 ADs (80%) occurred in patients with a CD4 T lymphocyte count of more than 200/mm3. Cases of autoimmune hemolytic anemia occurred only in patients severely immunodepressed. In five patients (a vasculitis case, a sarcoidosis case, three thyroid disease cases) the AD presented as a form of immune restoration inflammatory syndrome (IRIS). Some ADs allowed HIV-infection diagnosis at a stage of moderate immune deficiency (vasculitis, antiphospholipid syndrome, immune thrombocytopenia). 37 patients received immunosuppressant treatments with good tolerance. These results confirm in a large series of patients previous data concerning autoimmune diseases occurrence in HIV-infected people. In the HAART era, when HIV-infected people are treated more and more early, autoimmune diseases can occur, mainly at the phase of immunological recovery. HIV infection should not limit immunosuppressant treatment use.
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