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Resolution of 1-(2-Naphthyl)ethanol by a Combination of an Enzyme-Catalyzed Kinetic Resolution with a Fluorous Triphasic Separative Reaction

2002; American Chemical Society; Volume: 4; Issue: 15 Linguagem: Inglês

10.1021/ol026232f

1523-7060

Zhiyong Luo, Sauda Swaleh, Fritz Theil, Dennis P. Curran,

Pharmacogenetics and Drug Metabolism

[reaction: see text] Kinetic resolution of a fluorous ester rac-1 with Candida antarctica B lipase provided a mixture of enantioenriched alcohol (R)-2 and fluorous ester (S)-1. The mixture was subjected to a fluorous triphasic reaction to give both enantiomers of 1-(2-naphthyl)ethanol 2 in high ee without chromatographic separation or fluorous-organic liquid-liquid extractive purification.