Leucine and Protein Synthesis: mTOR and Beyond
2008; Oxford University Press; Volume: 65; Issue: 3 Linguagem: Inglês
10.1111/j.1753-4887.2007.tb00289.x
ISSN1753-4887
Autores Tópico(s)Pharmacological Effects and Assays
ResumoThe effects of amino acid intake on protein synthesis in the intact rat appear to be mediated almost entirely by a single amino acid: leucine. The effect of leucine on protein synthesis appears to be closely associated with eIF4G phosphorylation and its association with eIF4E, but whether eIF4G phosphorylation actually mediates the effects of leucine or is merely associated with these events has not been elucidated. Additional research is needed to determine whether leucine effects eIF4G phosphorylation, whether eIF4G phos-phorylation is essential for the effect of leucine on protein synthesis, and whether mTOR (mammalian target of rapamycin) or another component of the mTOR complex is somehow involved in leucine-specific signaling.
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