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Artigo Revisado por pares
BIBTEX RIS

Antibodies to ganglioside complexes consisting of asialo-GM1 and GQ1b or GT1a in Fisher and Guillain–Barré syndromes

2009; Elsevier BV; Volume: 214; Issue: 1-2 Linguagem: Inglês

10.1016/j.jneuroim.2009.06.017

ISSN

1872-8421

Autores

Go Ogawa, Kenichi Kaida, Susumu Kusunoki, Masami Ueda, Fumihiko Kimura, Keiko Kamakura,

Tópico(s)

Monoclonal and Polyclonal Antibodies Research

Resumo

To determine the epitopes of ganglioside complexes (GSCs) containing GQ1b or GT1a, we investigated their reactivity to GSCs consisting of asialo-GM1 (GA1) and GQ1b or GT1a using IgG anti-GQ1b- or anti-GT1a-positive sera. Nine anti-GQ1b-positive sera had higher activity to GA1/GQ1b than to GQ1b, only five of which reacted with GM1/GQ1b and GD1b/GQ1b. Five of 14 sera positive for GA1/GT1a and GM1/GT1a were negative for GA1/GQ1b and GM1/GQ1b. Sialic acids attached to the internal galactose of gangliotetraose can influence the reactivity of anti-GSC antibodies. Screening for antibodies to GSCs containing GA1 is useful for elucidation of the antibody-mediated pathophysiology.

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