Origins of tremor
2000; Elsevier BV; Volume: 355; Issue: 9210 Linguagem: Inglês
10.1016/s0140-6736(00)02054-7
ISSN1474-547X
Autores Tópico(s)Parkinson's Disease Mechanisms and Treatments
ResumoAlthough a very common movement disorder, tremor has defied simple pathophysiological explanations. The three commonest forms of pathological tremor are parkinsonian tremor, essential tremor, and cerebellar intention tremor. The distinctive neurophysiological pathways for these tremors have been surprisingly difficult to decipher. Coherence between low-frequency activation of the motor cortex and tremor in patients with essential tremorThe absence of significant coherence between the magnetoencephalogram and electromyogram at tremor frequencies suggests that in essential tremor the tremor is imposed on the active muscle through descending pathways other than those originating in the primary motor cortex. These findings challenge the model widely used to explain the efficacy of neurosurgical treatment of essential tremor, are in contrast to those of previous studies of parkinsonian rest tremor, and highlight an important difference in the pathophysiology of essential and parkinsonian tremor. Full-Text PDF
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