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Nakijiquinones G–I, new sesquiterpenoid quinones from marine sponge

2008; Elsevier BV; Volume: 16; Issue: 16 Linguagem: Inglês

10.1016/j.bmc.2008.07.028

1464-3391

Yohei Takahashi, Takaaki Kubota, Junji Ito, Yuzuru Mikami, Jane Fromont, Jun’ichi Kobayashi,

Synthetic Organic Chemistry Methods

Three new sesquiterpenoid quinones, nakijiquinones G–I (1–3), containing a different amino group derived from amino acids have been isolated from Okinawan marine sponges of the family Spongiidae, and the structures and relative stereochemistry of 1–3 were elucidated on the basis of the spectral data. Nakijiquinones G–I (1–3) showed modest cytotoxicity and inhibitory activity against HER2 kinase, while nakijiquinone H (2) exhibited antimicrobial activity.