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Antileishmanial and antifungal acridone derivatives from the roots of Thamnosma rhodesica

2004; Elsevier BV; Volume: 65; Issue: 7 Linguagem: Inglês

10.1016/j.phytochem.2003.12.020

1873-3700

Kouassi Maximin Ahua, Jean‐Robert Ioset, Adriana Ransijn, Jacques Mauël, Steven Mavi, Kurt Hostettmann,

Coleoptera Taxonomy and Distribution

Eight furanocoumarins, one coumarin and four acridone derivatives have been identified in the roots of Thamnosma rhodesica (Rutaceae). Rhodesiacridone, one of these acridone derivatives, is reported here for the first time. Its structure was elucidated by spectrometric methods including ESI-HR, EI, DCI mass spectrometry, 1H, 13C and 2D NMR experiments. This novel compound showed activities against the intracellular form of a human pathogen, the protozoan parasite Leishmania major. Two known acridone related compounds, gravacridonediol and 1-hydroxy-10-methylacridone, exhibited activities against the intracellular form of the same parasite and the fungus Cladosporium cucumerinum, respectively.