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Trypanocidal value of liposomal diminazene in experimental Trypanosoma brucei evansi infection in mice

1996; Elsevier BV; Volume: 61; Issue: 3-4 Linguagem: Inglês

10.1016/0304-4017(95)00827-6

1873-2550

Yang Yongsheng, Ou Yongchun, Ruan Chengmai, Cheng Yuan-guo, Zhang Fenqin,

Synthesis and Biological Evaluation

The trypanocidal value of liposomal diminazene was examined. Three hundred mice were divided randomly into six groups of 50 mice each. Groups 1, 2 and 3 were pretreated 2 h before Trypanosoma brucei evansi challenge with 0.2 ml saline solution, 0.2 ml diminazene solution (5 mg ml-1) and 0.2 ml liposomal solution (5 mg diminazene per ml), respectively. Mice in Group 1 all died within 6 days, 33 in Group 2 and four in Group 3 died within 15 days after challenge, respectively. Groups 4, 5, and 6 were treated 4 days after T. b. evansi challenge with 0.2 ml saline solution 0.2 ml diminazene solution (5 mg ml-1) and 0.2 ml liposomal solution (5 mg diminazene per ml), respectively. Mice in Group 4 all died within 6 days, 19 in Group 5 and two in group 6 died within 15 days after challenge, respectively. The remaining mice survived for more than 30 days, were symptom-free and behaved normally. No adverse effects associated with treatment were noted.