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Recurrent erythema migrans despite extended antibiotic treatment with minocycline in a patient with persisting Borrelia burgdorferi infection

1993; Elsevier BV; Volume: 28; Issue: 2 Linguagem: Inglês

10.1016/0190-9622(93)70043-s

1097-6787

Kenneth B. Liegner, Judith Shapiro, David L. Ramsay, Alan J. Halperin, Wayne Hogrefe, Lilly I. Kong,

Toxin Mechanisms and Immunotoxins

Erythema migrans recurred in a patient 6 months after a course of treatment with minocycline for Lyme disease. Polymerase chain reaction on heparinized peripheral blood at that time demonstrated the presence of Borrelia burgdorferi -specific DNA. The patient was seronegative by Lyme enzyme-linked immunosorbent assay but showed suspicious bands on Western blot. Findings of a Warthin-Starry stain of a skin biopsy specimen of the eruption revealed a Borrelia -compatible structure. Reinfection was not believed to have occurred. Further treatment with minocycline led to resolution of the erythema migrans.