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Australia antigen and primary biliary cirrhosis

1973; BMJ; Volume: 26; Issue: 5 Linguagem: Inglês

10.1136/jcp.26.5.335

1472-4146

R. N. M. MacSween, Albert A. C. Yeung Laiwah, Ashley Busuttil, Mair A. Thomas, Sheila K. Ross, G Watkinson, Irving Millman, B. S. Blumberg,

Liver Disease Diagnosis and Treatment

Sera from 64 patients with primary biliary cirrhosis have been examined for Australia antigen (Au). On immunodiffusion and immunoelectrophoresis all sera were negative. Using a radioimmunoprecipitation technique 15.6% of sera contained antigen compared with an incidence of 3.1% in matched controls, a significant difference (p = 0.015). Anti-Au was found in 9.4% of patients and in 7.8% of controls. In lymphocyte transformation studies lymphocytes from one of 24 patients with primary biliary cirrhosis transformed on stimulation with an Au-rich serum.