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Capsaicin and substance P

1991; Elsevier BV; Volume: 9; Issue: 4 Linguagem: Inglês

10.1016/0738-081x(91)90078-y

1879-1131

Joel E. Bernstein,

Neuropeptides and Animal Physiology

For centuries people have known that the seeds and membranes of certain species of plants of the nightshade family, notably capsicum, possess a principle that produces intense erythema, pain, and inflammation when applied to skin or mucous membrane. Capsicum was first referred to in 1494 by Chauca, a physician who accompanied Columbus on his second voyage to the West Indies. The active principle for this reaction and what makes hot pepper hot is known as capsaicin.