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The effect of exogenous testosterone on total and free prostate specific antigen levels in healthy young men

1996; Lippincott Williams & Wilkins; Volume: 156; Issue: 2 Linguagem: Inglês

10.1016/s0022-5347(01)65871-3

1527-3792

Christopher S. Cooper, John H. MacIndoe, Paul J. Perry, William R. Yates, Richard D. Williams,

Prostate Cancer Treatment and Research

No AccessJournal of UrologyClinical Urology: Original Article1 Aug 1996The effect of exogenous testosterone on total and free prostate specific antigen levels in healthy young men Christopher S. Cooper, John H. MacIndoe, Paul J. Perry, William R. Yates, and Richard D. Williams Christopher S. CooperChristopher S. Cooper More articles by this author , John H. MacIndoeJohn H. MacIndoe More articles by this author , Paul J. PerryPaul J. Perry More articles by this author , William R. YatesWilliam R. Yates More articles by this author , and Richard D. WilliamsRichard D. Williams More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65871-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the effect of exogenous testosterone administration on serum total and free prostate specific antigen (PSA) in healthy young men. Materials and Methods: Nine volunteers received either 100, 250 or 500 mg. testosterone by intramuscular injection each week for 15 weeks. Blood was drawn every other week for 28 weeks and at week 40. Serum total and free PSA, and total and free testosterone were measured and compared to baseline values. Results: Significant elevations in total and free testosterone occurred but no significant change in serum total and free PSA was detected. Conclusions: Serum PSA is not responsive to elevated serum testosterone levels in healthy young men. PSA metabolism in the normal prostate is unclear but our findings may have implications for differentiation of pathological conditions of the human prostate. References 1 : Human prostate-specific antigen: structural and functional similarity with serine proteases. Proc. Natl. Acad. Sci.1986; 83: 3166. 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Google Scholar Departments of Urology, Internal Medicine and Psychiatry, University of Iowa, Iowa City, Iowa.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byKhera M, Bhattacharya R, Blick G, Kushner H, Nguyen D and Miner M (2018) Changes in Prostate Specific Antigen in Hypogonadal Men After 12 Months of Testosterone Replacement Therapy: Support for the Prostate Saturation TheoryJournal of Urology, VOL. 186, NO. 3, (1005-1011), Online publication date: 1-Sep-2011.Cooper C, Perry P, Sparks A, MacIndoe J, Yates W and Williams R (2018) EFFECT OF EXOGENOUS TESTOSTERONE ON PROSTATE VOLUME, SERUM AND SEMEN PROSTATE SPECIFIC ANTIGEN LEVELS IN HEALTHY YOUNG MENJournal of Urology, VOL. 159, NO. 2, (441-443), Online publication date: 1-Feb-1998. Volume 156Issue 2August 1996Page: 438-442 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Christopher S. Cooper More articles by this author John H. 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