Small‐Molecule End‐Groups of Linear Polymer Determine Cell‐type Gene‐Delivery Efficacy
2009; Volume: 21; Issue: 48 Linguagem: Inglês
10.1002/adma.200901718
ISSN1521-4095
AutoresJoel Sunshine, Jordan J. Green, Kerry P. Mahon, Fan Yang, Ahmed A. Eltoukhy, David N. Nguyen, Róbert Langer, Daniel G. Anderson,
Tópico(s)Virus-based gene therapy research
ResumoEnd-modified polymers are promising for the nonviral delivery of genes to cancer cells, immune cells, and human stem cells and point to polymer end-groups as regulators for cell-type specificity. A library of polymers has been synthesized and, although some polymers are strong transfection agents overall, for each cell type, a particular polymer is most effective.
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