Portal de Periódicos da CAPES

Additional support for schizophrenia linkage on chromosomes 6 and 8: A multicenter study

1996; Wiley; Volume: 67; Issue: 6 Linguagem: Inglês

10.1002/(sici)1096-8628(19961122)67

1096-8628

Dieter B. Wildenauer, Sibylle G. Schwab, Margot Albus, Joachim Hallmayer, Bernard Lerer, Wolfgang Maier, Douglas Blackwood, Walter Muir, David St Clair, Stewart W. Morris, Hans W. Moises, Yang Liu, Helgi Kristbjarnarson, Tómas Helgason, Claudia Wiese, David Collier, Peter Holmans, Jo Daniels, Mark I. Rees, Philip Asherson, Queta Roberts, Alastair G. Cardno, María J. Arranz, Homero Vallada, David Ball, Hiroshi Kunugi, Robin M. Murray, John Powell, S. Nanko, Pak C. Sham, Michael Gill, Peter McGuffin, Michael J. Owen, Ann E. Pulver, Stylianos E. Antonarakis, Robert Babb, J L Blouin, Nicola DeMarchi, Beth A. Dombroski, David E. Housman, Maria Karayiorgou, Jürg Ott, Laura Kasch, Haig H. Kazazian, Virginia K. Lasseter, Erika Loetscher, H. Luebbert, Gerald Nestadt, Carl C.T. Ton, Paula Wolyniec, Claudine Laurent, Michel de Chaldée, Florence Thibaut, Maurice Jay, Danièle Samolyk, Michel Petit, Dominique Campion, Jacques Mallet, Richard E. Straub, Charles J. MacLean, Stephen M. Easter, F. Anthony O’Neill, Dermot Walsh, Kenneth S. Kendler, Pablo V. Gejman, Qiuhe Cao, Elliot S. Gershon, Judith A. Badner, Ethiopia Beshah, Jing Zhang, Brien P. Riley, Swarnageetha Rajagopalan, Mpala Mogudi-Carter, Trefor Jenkins, Robert Williamson, Lynn E. DeLisi, Chad Garner, Mary Margaret Kelly, Carrie LeDuc, Lon R. Cardon, Jay B. Lichter, Tim Harris, J. Loftus, Gail Shields, Margarite Comasi, Antonio Vita, Angela Smith, J.C. Dann, Geoff Joslyn, Hugh Gurling, Gursharan Kalsi, Jon Brynjolfsson, David Curtis, Thordur Sigmundsson, Robert J. Butler, Tim Read, Patrice Murphy, Andrew Chih-Hui Chen, Hannes Pétursson, Bill Byerley, Mark Hoff, John Holik, Hilary Coon, Douglas F. Levinson, Derek J. Nancarrow, Raymond R. Crowe, Nancy C. Andreasen, Jeremy M. Silverman, Richard C. Mohs, Larry J. Siever, Jean Endicott, Lawrence Sharpe, Marilyn K. Walters, David P. Lennon, Nicholas K. Hayward, Lodewijk A. Sandkuijl, Bryan Mowry, H.N. Aschauer, K. Meszaros, E. Lenzinger, Karoline Fuchs, Yang Liu, A. Heiden, Hans W. Moises, Leonid Kruglyak, Mark Daly, Tara C. Matise,

Autism Spectrum Disorder Research

In response to reported schizophrenia linkage findings on chromosomes 3, 6 and 8, fourteen research groups genotyped 14 microsatellite markers in an unbiased, collaborative (New) sample of 403–567 informative pedigrees per marker, and in the Original sample which produced each finding (the Johns Hopkins University sample of 46–52 informative pedigrees for chromosomes 3 and 8, and the Medical College of Virginia sample of 156–191 informative pedigrees for chromosome 6). Primary planned analyses (New sample) were two-point heterogeneity lod score (lod2) tests (dominant and recessive affected-only models), and multipoint affected sibling pair (ASP) analysis, with a narrow diagnostic model (DSM-IIIR schizophrenia and schizoaffective disorders). Regions with positive results were also analyzed in the Original and Combined samples. There was no evidence for linkage on chromosome 3. For chromosome 6, ASP maximum lod scores (MLS) were 2.19 (New sample, nominal p = .001) and 2.68 (Combined sample, p=.0004). For chromosome 8, maximum lod2 scores (tests of linkage with heterogeneity) were 2.22 (New sample, p=.0014) and 3.06 (Combined sample, p = .00018). Results are interpreted as inconclusive but suggestive of linkage in the latter two regions. We discuss possible reasons for failing to achieve a conclusive result in this large sample. Design issues and limitations of this type of collaborative study are discussed, and it is concluded that multicenter follow-up linkage studies of complex disorders can help to direct research efforts toward promising regions.