Mapping of Unconventional Myosins in Mouse and Human
1996; Elsevier BV; Volume: 36; Issue: 3 Linguagem: Inglês
10.1006/geno.1996.0488
ISSN1089-8646
AutoresTama Hasson, Joseph F. Skowron, Debra J. Gilbert, Karen B. Avraham, William L. Perry, William M. Bement, Blake Anderson, Elliott H. Sherr, Zheng‐Yi Chen, Lloyd A. Greene, David C. Ward, David P. Corey, Mark S. Mooseker, Neal G. Copeland, Nancy A. Jenkins,
Tópico(s)Muscle Physiology and Disorders
ResumoMyosins are molecular motors that move along filamentous actin. Seven classes of myosin are expressed in vertebrates: conventional myosin, or myosin-II, as well as the 6 unconventional myosin classes -I, -V, -VI, -VII, -IX, and -X. We have mapped in mouse 22 probes encompassing all known unconventional myosins and, as a result, have identified 16 potential unconventional myosin genes. These genes include 7 myosins-I, 2 myosins-V, 1 myosin-VI, 3 myosins-VII, 2 myosins-IX, and 1 myosin-X. The map location of 5 of these genes was identified in human chromosomes by fluorescencein situhybridization.
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