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BIBTEX RIS

Pyridindolols K1 and K2, New Alkaloids from Streptomyces sp. K93-0711.

1997; Springer Nature; Volume: 50; Issue: 3 Linguagem: Inglês

10.7164/antibiotics.50.189

ISSN

1881-1469

Autores

Yong-Pil Kim, Satoshi Takamatsu, Masahiko Hayashi, Kanki Komiyama, Satoshi Ōmura,

Tópico(s)

Fungal Biology and Applications

Resumo

Two new alkaloids with the β-carboline skeleton, pyridindolols Kl (C18H18N2O5) and K2 (C16H16N2O4), were isolated from the culture broth of Streptomyces sp. K93-0711. The structure of pyridindolols were established by spectroscopic investigations and chemical transformations. Pyridindolol K2 inhibited the adhesion of HL-60 cells to LPS-activated HUVEC monolayer (IC50=75μg/ml).

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