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Codon—anticodon pairing: The wobble hypothesis

1966; Elsevier BV; Volume: 19; Issue: 2 Linguagem: Inglês

10.1016/s0022-2836(66)80022-0

1089-8638

Francis Crick,

Genomics and Phylogenetic Studies

It is suggested that while the standard base pairs may be used rather strictly in the first two positions of the triplet, there may be some wobble in the pairing of the third base. This hypothesis is explored systematically, and it is shown that such a wobble could explain the general nature of the degeneracy of the genetic code.