α2-Adrenoceptor modulation of long-term potentiation elicited in vivo in rat occipital cortex
2004; Elsevier BV; Volume: 1021; Issue: 2 Linguagem: Inglês
10.1016/j.brainres.2004.07.020
ISSN1872-6240
AutoresMauricio Mondaca, Alejandro Hernández, Hernán Pérez, Luis Valladares, Walter Sierralta, Víctor Manuel Fernández, Rubén Soto‐Moyano,
Tópico(s)Anesthesia and Neurotoxicity Research
ResumoPretreatment with the alpha(2)-adrenoceptor agonist clonidine (31.25, 62.5, or 125 microg/kg, i.p.) dose-dependently reduced long-term potentiation (LTP) elicited in vivo in the occipital cortex of anesthetized rats, whereas pretreatment with the alpha(2)-adrenoceptor antagonist yohimbine (0.133, 0.4, or 1.2 mg/kg, i.p.) increased neocortical LTP in a dose-dependent fashion. These effects could be related to the reported disruptive and facilitatory actions induced on memory formation by pretreatment with alpha(2)-adrenoceptor agonists and antagonists, respectively.
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