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Low-dose ultraviolet-B irradiation depletes human epidermal Langerhans cells

1993; Oxford University Press; Volume: 129; Issue: 6 Linguagem: Inglês

10.1111/j.1365-2133.1993.tb03330.x

1365-2133

Gillian Murphy, P.G. NORRIS, Antony R. Young, Mandy Corbett, J.L.M. HAWK,

Neonatal skin health care

We have examined the effects of low‐dose monochromatic UVB irradiation (295±5 nm), biologically equivalent to that generally incident on the skin during a 12‐session sun‐bed course, on the expression of the CDla epidermal Langerhans cell surface marker in human skin in vivo. In five subjects, 1.5 minimal erythema doses (MEDs) at 295 nm depleted its expression by 50%. In five further subjects, a single 1.5 MED dose, 1.5 MEDs in 10 equal fractions on alternate days, and a single 1.5 MED dose at one‐tenth the previously used irradiance, delivered to separate sites, also led to variable but significant depletion of CD la expression of around‐30–50%. Thus, low‐dose UVB irradiation, whether received rapidly or slowly, appears significantly and approximately equally to deplete human epidermal Langerhans cell numbers as measured by CDla expression.